Mario Senden is a computational neuroscientist whose research aims to bridge the gap between biophysically realistic brain simulation and functional, behavior-producing artificial intelligence. He develops next-generation models that incorporate biological constraints, such as connectome architectures and laminar microcircuits, while being trained end-to-end on complex tasks. The goal of this work is to create truly functional whole-brain models to understand how large-scale neural dynamics give rise to intelligent behavior.
